Rabbit Secondary Antibodies
ABclonal Technology 488 Rabbit anti-Human CD58
This gene encodes a member of the immunoglobulin superfamily The encoded protein is a ligand of the T lymphocyte CD2 protein and functions in adhesion and activation of T lymphocytes The protein is localized to the plasma membrane Alternatively spliced transcript variants have been described
ABclonal Technology 488 Rabbit anti-Human CD58
This gene encodes a member of the immunoglobulin superfamily The encoded protein is a ligand of the T lymphocyte CD2 protein and functions in adhesion and activation of T lymphocytes The protein is localized to the plasma membrane Alternatively spliced transcript variants have been described
ABclonal Technology PE Rabbit anti-Human CD7 mAb
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily This protein is found on thymocytes and mature T cells It plays an essential role in T-cell interactions and also in T-cell B-cell interaction during early lymphoid development
ABclonal Technology PE Rabbit anti-Mouse CD23 mAb
Predicted to enable carbohydrate binding activity Acts upstream of or within positive regulation of humoral immune response mediated by circulating immunoglobulin Located in external side of plasma membrane Orthologous to human FCER2 (Fc fragment of IgE receptor II)
ABclonal Technology ABflo 594 Rabbit anti-Rat CD31
Enables protein phosphatase binding activity Involved in several processes including cellular response to interferon-gamma negative regulation of GTPase activity and negative regulation of actin filament polymerization Located in cell surface and ruffle Used to study pulmonary hypertension Biomarker of bacterial pneumonia orchitis and osteoarthritis Human ortholog(s) of this gene implicated in coronary artery disease (multiple) lung non-small cell carcinoma neuroblastoma and psoriatic arthritis Orthologous to human PECAM1 (platelet and endothelial cell adhesion molecule 1)
ABclonal Technology 647 Rabbit anti-Human CD116
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2 a cytokine which controls the production differentiation and function of granulocytes and macrophages The encoded protein is a member of the cytokine family of receptors This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes Multiple transcript variants encoding different isoforms have been found for this gene with some of the isoforms being membrane-bound and others being soluble
ABclonal Technology HSP40 Rabbit mAb
This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins DNAJ family members are characterized by a highly conserved amino acid stretch called the J-domain and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events such as protein folding and oligomeric protein complex assembly The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation Alternative splicing results in multiple transcript variants
ABclonal Technology ICAM5 Rabbit mAb
Predicted to enable integrin binding activity Acts upstream of or within phagocytosis Located in plasma membrane Is expressed in brain Orthologous to human ICAM5 (intercellular adhesion molecule 5)
Abcam Rabbit Anti-Mouse IgG H&L (TRITC).
Rabbit Anti-Mouse IgG H&L (TRITC).
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology 647 Rabbit anti-Human CD177
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration Mutations in this gene are associated with myeloproliferative diseases Over-expression of this gene has been found in patients with polycythemia rubra vera Autoantibodies against the protein may result in pulmonary transfusion reactions and it may be involved in Wegener s granulomatosis A related pseudogene which is adjacent to this gene on chromosome 19 has been identified
ABclonal Technology PE Rabbit anti-Human CD40 mAb
This gene is part of the TNF-receptor superfamily encoding a receptor on antigen-presenting cells that mediates immune and inflammatory responses including T cell-dependent immunoglobulin class switching memory B cell development and germinal center formation It is regulated by the AT-hook transcription factor AKNA which controls both the receptor and its ligand aiding in homotypic cell interactions The receptor interacts with TNFR2 to mediate signal transduction and is essential for amyloid-beta-induced microglial activation an early event in Alzheimer s disease Mutations in this gene cause autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3) Multiple splice variants encoding different isoforms have been identified
ABclonal Technology 647 Rabbit anti-Human CD58
This gene encodes a member of the immunoglobulin superfamily The encoded protein is a ligand of the T lymphocyte CD2 protein and functions in adhesion and activation of T lymphocytes The protein is localized to the plasma membrane Alternatively spliced transcript variants have been described
ABclonal Technology PE Rabbit anti-Mouse IgG1 mAb
Mouse IgG1 is a subtype of immunoglobulin G antibody that is produced by B cells in response to an antigen It is the most abundant IgG subtype in the serum and plays a crucial role in the adaptive immune response Mouse IgG1 is composed of two heavy chains and two light chains and it is involved in opsonization complement activation and antibody-dependent cell-mediated cytotoxicity It is also involved in the regulation of immune responses including the activation of T cells and the inhibition of B cell activation Mouse IgG1 is widely used in research and diagnostic applications including ELISA Western blotting and immunohistochemistry It is also used in therapeutic applications such as immunotherapy and vaccine development
ABclonal Technology 488 Rabbit anti-Human CD1d
This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 647 Rabbit anti-Human CD4
This gene encodes the CD4 membrane glycoprotein of T lymphocytes The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit This gene is expressed not only in T lymphocytes but also in B cells macrophages granulocytes as well as in various regions of the brain The protein functions to initiate or augment the early phase of T-cell activation and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene